General
Preferred name
Tilfrinib
Synonyms
P&D ID
PD071465
CAS
1600515-49-8
Tags
available
probe
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
High-quality chemical probes
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC50 value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour[1][2].
PRICE 94
DESCRIPTION Tilfrinib, a pyridoindol derivative, has been found to be a breast tumor kinase (Brk) inhibitor that could probably restrain the proliferation of breast cancer cells. IC50: 3.15 nM. (BOC Sciences Bioactive Compounds)
DESCRIPTION Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities. (TargetMol Bioactive Compound Library)
DESCRIPTION Type I BMP receptor inhibitor (Tocris Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
12
Axon Medchem Screening Library
2560
BOC Sciences Bioactive Compounds
tilfrinib-cas-1600515-49-8-item-475889
Cayman Chemical Bioactives
25647
CZ-OPENSCREEN Bioactive Library
EUbOPEN Chemogenomics Library
EUB0001917
High-quality chemical probes
PD071465
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL3133821
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL3133821
MedChem Express Bioactive Compound Library
HY-110244
Probe Miner (suitable probes)
Q13882/1285572
TargetMol Bioactive Compound Library
T17098
Tocris Bioactive Compound Library
5579
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
275.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
4
cLogP
4.17
TPSA
60.94
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
BRK
Brk inhibitor
Primary Target
Src Kinases
MOA
Inhibitor
Pathway
Angiogenesis
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Solubility
DMSO: 100 mM
Recommended Cell Concentration
None
Source data